国际眼科纵览

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近视发病机制的表观遗传学研究

张楚,朱子诚,展欣,应充慧   

  1. 230001合肥,安徽医科大学附属省立医院 中国科学技术大学附属第一医院眼科(张楚系在读硕士研究生)
  • 收稿日期:2018-03-18 出版日期:2018-12-22 发布日期:2018-12-22
  • 通讯作者: 朱子诚,Email:zczhu123@163.com
  • 基金资助:

    安徽省自然科学基金(1508085MH188);安徽省教育厅教学研究项目(2016jyxm0546)

Progress of epigenetics study in the pathogenesis of myopia

ZHANG Chu, ZHU Zi-cheng, ZHAN Xin, YING Chong-hui   

  1. Department of Ophthalmology, Provincial Hospital Affiliated of Anhui Medical University, The First Affilated Hospital of University of Science and Technology of China, Hefei 230001, China
  • Received:2018-03-18 Online:2018-12-22 Published:2018-12-22
  • Contact: ZHU Zi-cheng,Email:zczhu123@163.com
  • Supported by:

    Anhui Natural Science Foundation(1508085MH188);Education Department of Anhui Province Teaching Research Project(2016jyxm0546)

摘要:

近视的发病机制仍不清楚,遗传和环境因素可能起重要作用。表观遗传学的研究推动了人们对近视发病机制的了解。表观遗传学包括DNA甲基化作用、组蛋白修饰作用和非编码RNA等。启动子区域CpG岛DNA甲基化及一些miRNAs的表达变化,可能参与了近视的发病。(国际眼科纵览, 2018,  42:    393-395)

Abstract:

The pathogenesis of myopia is unclear. Genetic and environmental factors may play an important role.  Recent studies in epigenetics have promoted the understanding of the pathogenesis of myopia. Epigenetics includes DNA methylation, histone modification and non-coding RNA. DNA methylation in the promoter region CpG island and changes in the expression of some miRNAs may be involved in the progression of myopia. (Int Rev Ophthalmol, 2018, 42:   393-395)