国际眼科纵览 ›› 2022, Vol. 46 ›› Issue (5): 402-409.doi: 10.3760/ cma.j.issn.1673-5803.2022.05.004

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吸烟与眼部疾病关系的研究进展

何海龙1 周春媛2 刘振宇1 金子兵1   

  1. 1首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 眼科学与视觉科学北京市重点实验室 100730;2北京市房山区良乡医院眼科 102401
  • 收稿日期:2022-01-28 出版日期:2022-10-22 发布日期:2022-11-04
  • 通讯作者: 金子兵,Email:jinzb502@ccmu.edu.cn E-mail:jinzb502@ccmu.edu.cn

Smoking and ocular diseases

He Hailong1, Zhou Chunyuan2, Liu Zhenyu1, Jin Zibing1   

  1. 1 Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; 2 Department of Ophthalomology, Liangxiang Hospital of Beijing Fangshan District, Beijing 102401, China
  • Received:2022-01-28 Online:2022-10-22 Published:2022-11-04
  • Contact: Jin Zibing,Email:jinzb502@ccmu.edu.cn E-mail:jinzb502@ccmu.edu.cn

摘要: 吸烟与多种眼部疾病相关。吸烟可通过炎性因子白介素(interleukin, IL)-1β 及IL-6的释放、核因子-κB的激活导致干眼的发生;并可增加白内障、年龄相关性黄斑变性的患病风险。吸烟者血清甲状腺相关抗体浓度下降,甲状腺相关眼病的进展情况较不吸烟者严重。吸烟引起的氧化应激反应造成血管内皮损伤,可能是其与缺血相关眼病、青光眼、翼状胬肉及屈光不正等眼病相关的重要机制。(国际眼科纵览,2022, 46:402-409)

关键词: 吸烟, 眼科疾病, 危险因素

Abstract: Smoking could be detrimental to multiple ocular diseases. The release of IL-1β and IL-6 together with activation of NF-κB was prompted by cigarette smoking may be associated with dry eye. Some studies found smoking was statistically significantly associated with increased risk of cataract and age-related macular degeneration (AMD). Cigarette smoking was related to a significant decline in the concentrations of serum thyroxine antibody in thyroid-associated ophthalmopathy (TAO) patients. Ischemia-related eye diseases, glaucoma, pterygium, refractive error, and other eye diseases that may be associated with systemic vascular endothelial dysfunction caused by smoking.(Int Rev Ophthalmol, 2022, 46: 402-409)

Key words: smoking, ocular disease, risk factors