关键词: 微小RNA, 角膜损伤, 损伤修复

Abstract: MicroRNA has a critical role in corneal wound healing. A complex and regulated sequence of cellular reactions involve cell death, migration, proliferation, differentiation, and extracellular matrix remodeling. Distributed in different levels of cornea, microRNA is a key regulator in growth factors, cytokines and signaling pathways downstream. Variety of microRNAs simultaneously modulates multiple signaling pathways and represents a complex and precise regulatory network to participate in the cascade reaction of corneal wound healing. Meanwhile, the deposition of extracellular matrix and the angiogenesis caused by the altered microRNA expression indicates the importance of microRNA in corneal pathological repair.(Int Rev Ophthalmol, 2021, 45: 246-250)

Key words: microRNA, cornea injury, wound healing