关键词: 成年人弱视, 视皮层损伤, 视皮层可塑性, 关键期

Abstract: Adult visual cortex plasticity may be associated with "brakes", visual related signaling pathways and cellular molecules. “Brakes” limit plasticity by altering neural transmission between parts and connections, blocking these "brakes" can promote the recovery of dendritic spines density in pyramidal cells of the visual cortex, increase the frequency of miniature excitatory synaptic current and spinal density on neuron dendrites, and enhance visual evoked potential to reactivate the plasticity in adult visual cortex plasticity and treat amblyopia. The abnormity of NRG1-ErbB4 and PSA-NCAM signaling pathways also change the plasticity, structure and function of neuron morphology. The blocking of N-methyl-D-aspartate-receptor, cyclin-dependent kinase 5 and histone deacetylase can promote long-term potentiation, regulate V1 chromatin structure and transcription in adults to regulate reactivation of visual cortex plasticity in adults.(Int Rev Ophthalmol, 2021, 45: 550-555)

Key words: adult amblyopia, visual cortex injury, visual cortical plasticity, critical period