国际眼科纵览 ›› 2021, Vol. 45 ›› Issue (6): 471-476.doi: 10.3760/cma.j.issn.1673-5803.2021.06.002

• 综述 • 上一篇    下一篇

棕榈酰乙醇胺治疗青光眼的机制

唐丽颖1,2  谢婷玉2  张谋鑫3  刘祖国1   

  1. 1厦门大学眼科研究所 361022;2厦门大学附属中山医院眼科 361004;3厦门大学附属厦门眼科中心 361004

  • 收稿日期:2021-03-15 出版日期:2021-12-22 发布日期:2021-12-22
  • 通讯作者: 刘祖国,Email:zuguoliu@xmu.edu.cn
  • 基金资助:
    国家重点研发计划(2018YFA0107304);国家自然科学基金(81870627);中央高校基本科研基金(20720202013)

The mechanism of palmitoethanolamide in the treatment of glaucoma

Tang Liying1,2, Xie Tingyu2, Zhang Mouxin3, Liu Zuguo1   

  1. 1Eye Institute of Xiamen University, Xiamen 361022, China; 2Department of Ophthalmology, Zhongshan Hosipital of Xiamen University, Xiamen 361004, China; 3Affiliated Xiamen Eye Center of Xiamen University, Xiamen 361004, China

  • Received:2021-03-15 Online:2021-12-22 Published:2021-12-22
  • Contact: Liu Zuguo, Email: zuguoliu@xmu.edu.cn
  • Supported by:
    National Key R&D Program of China(2018YFA0107304); National Natural Science Foundation of China(81870627);  Fundamental Research Funds for the Central Universities(20720202013)

摘要: 棕榈酰乙醇胺(palmitoylethanolamide,PEA)是脂肪酸乙醇酰胺家族成员之一,具有调节房水流出通道、抑制炎性反应、调节视神经血供等作用,可能通过降低眼压、改善视神经血供和神经保护作用成为青光眼治疗的一个新途径。(国际眼科纵览,2021, 45:471-476)


关键词: 棕榈酰基乙醇胺, 青光眼, 眼压, 神经保护

Abstract: Palmitoylethanolamide(PEA) is a member of fatty acid ethanolamide(FAE) family. At present, PEA has been proved to reduce intraocular pressure, regulate blood supply of optic nerve and neuroprotective effects, and may become a new approach for the treatment of glaucoma. PEA may treat glaucoma by regulating aqueous outflow channel, inhibiting inflammatory response, regulating blood supply to optic nerve and protecting optic nerve. (Int Rev Ophthalmol, 2021, 45: 471-476)


Key words: N-palmitoylethanolamide, glaucoma, intraocular pressure, nerve protection