国际眼科纵览 ›› 2022, Vol. 46 ›› Issue (2): 130-133.doi: 10.3760/cma.j.issn.1673-5803.2022.02.006

• 综述 • 上一篇    下一篇

儿童单纯疱疹病毒性角膜炎研究进展

黄美婷  晏晓明   

  1. 北京大学第一医院眼科 100034
  • 收稿日期:2021-07-27 出版日期:2022-04-22 发布日期:2022-04-24
  • 通讯作者: 晏晓明,Email:yanxiaoming7908@163.com

Herpes simplex keratitis in children

Huang Meiting, Yan Xiaoming   

  1. Department of Ophthalmology, the First Hospital of Peking University, Beijing 100034, China
  • Received:2021-07-27 Online:2022-04-22 Published:2022-04-24
  • Contact: Yan Xiaoming, Email:yanxiaoming7908@163.com

摘要: 儿童单纯疱疹病毒性角膜炎(herpes simplex keratitis,HSK)发病形式、诊断、治疗、复发及预防等与成年人有较大差异,常伴发较为严重的并发症。儿童HSK较成年人HSK更易造成全身播散。其误诊率可达15%~30%。儿童HSK双眼受累的发生率为10%~26%。最常见类型为基质型(几率为35%~50%)。较成年人易复发。其诊断依靠病史及临床表现、病毒培养及PCR检测等。在治疗和预防方面,目前的研究主要强调了口服抗病毒药物阿昔洛韦、伐昔洛韦等的作用。(国际眼科纵览,2022, 46:130-133)


关键词: 单纯疱疹病毒性角膜炎, 儿童

Abstract: Herpes simplex keratitis (HSK) in children differs significantly from adults in its form of development, diagnosis, treatment, recurrence, and prevention, and is often associated with more serious complications. HSK in children is more likely to cause systemic dissemination than adults. The misdiagnosis rate can reach from 15% to 30%. The incidence rate of binocular involvement in children HSK was from 10% to 26%. The most common type of HSK in children is corneal stromal type (the probability is from 35% to 50%). It is more likely to recur than in adults. The diagnosis of HSK in children generally depends on clinical history and manifestations, virus culture and PCR. In terms of treatment and prevention, current research mainly emphasizes the role of oral antiviral drugs such as acyclovir, valaciclovir.(Int Rev Ophthalmol, 2022, 46:  130-133)


Key words: herpes simplex keratitis, children