晶状体衰老机制的研究

doi:10.3760/ cma.j.issn.1673-5803.2021.06.012

国际眼科纵览 ›› 2021, Vol. 45 ›› Issue (6): 529-534.doi: 10.3760/ cma.j.issn.1673-5803.2021.06.012

晶状体衰老机制的研究

付宇姗周南齐艳华

哈尔滨医科大学附属第二医院眼科 150086

收稿日期:2021-03-16 出版日期:2021-12-22 发布日期:2021-12-22
通讯作者: 齐艳华，Email：qyh86605643@126.com

Research on the mechanism of lenticular senescence

Fu Yushan, Zhou Nan, Qi Yanhua

Department of Ophthalmology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China

Received:2021-03-16 Online:2021-12-22 Published:2021-12-22
Contact: Qi Yanhua, Email: qyh86605643@126.com

摘要/Abstract

摘要： 晶状体上皮细胞是晶状体代谢的中枢，其衰老会导致白内障的发生。晶状体上皮细胞端粒长度的缩短、细胞内氧化应激状态的长期存在并激活多条炎症通路、细胞自噬活性的降低以及抗衰老酶SIRT的失活均参与疾病发展过程。同时晶状体内蛋白质、脂质稳态的破坏以及水平衡失衡等均会加速晶状体衰老进程。（国际眼科纵览，2021, 45：529-534）

关键词:

白内障；晶状体上皮细胞；晶状体衰老 ,

Abstract:

Lens epithelium is the center of lens metabolism, and its senescence will lead to cataract. Several mechanisms are involved in the progression of cataract including: shortening of telomere length in lens epithelial cells, the long-term existence of intracellular oxidative stress activating multiple inflammatory pathways involved in cell signaling, decreased autophagy activity, and the inactivation of the anti-aging enzyme -SIRT. Meanwhile, the damage of protein and lipid homeostasis in lens and the imbalance of water balance will accelerate the process of lens aging. (Int Rev Ophthalmol, 2021, 45: 529-534)

Key words: cataract, lens epithelial cells, lenticular senescence

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付宇姗周南齐艳华. 晶状体衰老机制的研究[J]. 国际眼科纵览, 2021, 45(6): 529-534.

Fu Yushan, Zhou Nan, Qi Yanhua. Research on the mechanism of lenticular senescence[J]. International Review of Ophthalmology, 2021, 45(6): 529-534.

晶状体衰老机制的研究

Research on the mechanism of lenticular senescence

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