国际眼科纵览 ›› 2022, Vol. 46 ›› Issue (1): 22-28.doi: 10.3760/ cma.j.issn.1673-5803.2022.01.005

• 综述 • 上一篇    下一篇

人工晶状体表面改性防治后发性白内障

李猛 毛迎燕 万修华   

  1. 首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所眼科学与视觉科学北京市重点实验室100005
  • 收稿日期:2021-03-03 出版日期:2022-02-22 发布日期:2022-03-14
  • 通讯作者: 万修华,Email:wanxh@ccmu.edu.cn E-mail:wanxh@ccmu.edu.cn
  • 基金资助:
    北京市医院管理中心临床医学发展专项经费(XMLX202133)

Intraocular lens modification for prevention of posterior capsule opacification

Li Meng, Mao Yingyan, Wan Xiuhua   

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China
  • Received:2021-03-03 Online:2022-02-22 Published:2022-03-14
  • Contact: Wan Xiuhua, Email: wanxh@ccmu.edu.cn E-mail:wanxh@ccmu.edu.cn
  • Supported by:
    Beijing Hospitals Authority Clinical Medicine Development of Special Funding(XMLX202133)

摘要: 后发性白内障(posterior capsule opacification, PCO)是白内障术后最常见的并发症。PCO是由白内障术后残留的晶状体上皮细胞增生、迁移、上皮-间充质转化和白内障术后的创伤愈合反应而形成的。通过对人工晶状体(intraocular lens,IOL)进行表面改性来防治PCO具有靶向性强、减少后续医疗干预等优点。根据IOL改性的效应材料,可以将IOL改性分为药物负载和非药物改性两大类。根据预防或抑制PCO的效应是否可以控制,可将其分为可控改性和非可控改性。(国际眼科纵览,2022, 46:22-28)

关键词: 人工晶状体, 后发性白内障, 晶状体上皮细胞, 上皮-间充质转化

Abstract: Posterior capsule opacification (PCO) is the most common complication after cataract surgery. PCO is formed by the proliferation, migration, epithelial-mesenchymal transition, and wound healing reaction of the residual lens epithelial cells after cataract surgery. Modification of the intraocular lens (IOL) to prevent and treat PCO has the advantages of excellent targeting efficiency and fewer follow-up medical intervention. According to the effect materials of IOL modification, it can be classified into two types: drug loading and non-drug modification. According to whether the effect of preventing or inhibiting PCO can be controlled, it can be classified into the controllable modification and non-controllable modification. (Int Rev Ophthalmol, 2022, 46: 22-28)

Key words: intraocular lens, posterior capsule opacification, lens epithelial cell, epithelial-mesenchymal transition