关键词: 泪腺腺样囊性癌, 小RNA 

Abstract: Lacrimal gland adenoid cystic carcinoma(LGACC) is a common malignant epithelial tumor of  lacrimal gland, which has high recurrence rate and metastasis rate. In recent years, it has been found that a variety of microRNAs play an important role in the occurrence and development of LGACC. Overexpression of miR-24-3p can promote the expression of p53 / p21 by reducing the expression of PRKCH in LGACC, so as to inhibit tumor invasion. MiR-93-5p regulates Wnt signaling pathway and down regulates breast cancer metastasis suppressor 1 (BRMS1) L, and promotes epithelial mesenchymal transition (EMT), migration, invasion and proliferation of LGACC cells. The up-regulated expression of miR-181a-5p in LGACC is also one of the reasons for the proliferation and migration of LGACC cells. (Int Rev Ophthalmol, 2022, 46:  157-161)

Key words: lacrimal gland adenoid cystic carcinoma, microRNA