珍芪滴眼液熏蒸疗法对干眼的短期疗效

doi:10.13281/j.cnki.issn.1004-4469.2016.05.015

眼科

珍芪滴眼液熏蒸疗法对干眼的短期疗效

张海娟黄蓉张俊秀武宇影马科

100005 首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所眼科学与视觉科学北京市重点实验室

收稿日期:2016-01-12 出版日期:2016-09-25 发布日期:2016-09-26
通讯作者: 马科，Email：cdmake@163.com
基金资助:
十二五“重大新药创制”国家科技重大专项基金（2011ZX09302-007-05）

The short-term efficacy of Zhenqi eye drop steam massage on the treatment of dry eye

ZHANG Hai-juan, HUANG Rong, ZHANG Jun-xiu, WU Yu-ying, MA Ke

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China

Received:2016-01-12 Online:2016-09-25 Published:2016-09-26
Contact: MA Ke, Email: cdmake@163.com

摘要/Abstract

摘要：

目的观察珍芪滴眼液熏蒸疗法对干眼的疗效。设计前瞻性、随机、开放、阳性滴眼液平行对照的临床试验。研究对象 2013-2015年北京同仁医院眼科门诊干眼患者96例，平均年龄（60.95±12.22）岁。方法 96例受试者随机分为试验组与对照组，各48例。两组均给予玻璃酸钠滴眼液，每日4次，每次1滴。在此基础上，试验组使用珍芪滴眼液熏蒸疗法，每天1次，每次20分钟。对照组给予珍芪滴眼液点眼，每日4次，每次1滴。观察用药4周受试者干眼症状及体征改善情况。主要指标 总有效率（临床显效+有效）、症状总分、Schirmer I试验（schirmer I test, SIt）、泪膜破裂时间（break-up time, BUT）、角膜荧光素染色评分。结果治疗前试验组与对照组在症状总分、SIt、BUT、角膜荧光素染色计分上均无显著性差异。治疗4周试验组总有效率（81.25%）明显高于对照组（62.50%）（P=0.041）。治疗4周时试验组BUT为（7.53±3.78）s，对照组为（6.08±2.99）s，试验组明显高于对照组（P=0.041）。症状总分试验组为1.92±1.99，对照组为2.32±2.30，试验组明显低于对照组（P=0.031）。结论珍芪滴眼液熏蒸疗法能有效治疗干眼，在玻璃酸钠滴眼液的基础上，该疗法优于珍芪滴眼液点眼治疗。（眼科，2016, 25： 347－350）

关键词: 干眼, 中药熏蒸按摩

Abstract:

Objective To observe the efficacy of Zhenqi eye drop steam massage on dry eye patients. Design A perspective, randomized, opening, positive eye drop parallel controlled clinical study. Participants All the 96 patients were observed in Tongren hospital from 2013 to 2015 in out patients, the mean age was 60.95±12.22 year old. Methods Ninety-six patients with dry eye were randomly divided into two groups, the testing group and the control group, with 1 by 1 ratio. The testing group and the control group were both given vitrobolik eye drops, 4 times a day. In addition, the testing group were given Zhenqi eye drop stream massage, 20 min per day, and the control group were given Zhenqi eye drop 4 times a day without steam massage. All the patients were observed for 4 weeks for the improvement of symptoms and clinical signs. Main Outcome Measures The clinical effectiveness ratio, total scores of symptoms, Schimer I test(SIt), tear break-up time(BUT), cornea fluororencein staining. Results There were no significant difference between testing group and control groups in total scores of symptoms, SIt, tear BUT, cornea fleuororencein staining before treatment. The clinical effectiveness ratio was 81.25% in the testing group, significantly higher than 62.50% (P=0.041) in the control group after 4-week treatment. And the tear BUT improved significantly in testing group 7.53±3.78 s than in the control group(P=0.041). The total score of symptom was 1.92±1.99 in the testing group and 2.32±2.30 in the control group(P=0.031). Conclusion Dry eye can be effectively treated using Zhenqi eye drop steam massage. The efficacy of Zhenqi eye drop steam massage was better than vitrobolik eye drop. （Ophthalmol CHN, 2016, 25： 347－350）

Key words: dry eye, herbs stream massage

张海娟黄蓉张俊秀武宇影马科. 珍芪滴眼液熏蒸疗法对干眼的短期疗效[J]. 眼科, doi: 10.13281/j.cnki.issn.1004-4469.2016.05.015.

ZHANG Hai-juan, HUANG Rong, ZHANG Jun-xiu, WU Yu-ying, MA Ke. The short-term efficacy of Zhenqi eye drop steam massage on the treatment of dry eye[J]. Ophthalmology in China, doi: 10.13281/j.cnki.issn.1004-4469.2016.05.015.

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珍芪滴眼液熏蒸疗法对干眼的短期疗效

The short-term efficacy of Zhenqi eye drop steam massage on the treatment of dry eye

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