眼科 ›› 2021, Vol. 30 ›› Issue (5): 333-336.doi: 10.13281/j.cnki.issn.1004-4469.2021.05.002

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关于原发性闭角型青光眼发病机制的几点思考

任泽钦   

  1. 北京大学人民医院眼科 100044
  • 收稿日期:2021-08-26 出版日期:2021-09-25 发布日期:2021-09-24
  • 通讯作者: 任泽钦,Email:renzeqin@163.com

Some thoughts on the pathogenesis of primary angle-closure glaucoma

Ren Zeqin   

  1. Department of Ophthalmology, Peking University People Hospital, Beijing 100044, China
  • Received:2021-08-26 Online:2021-09-25 Published:2021-09-24
  • Contact: Ren Zeqin, Email: renzeqin@163.com

摘要: 目前对原发性闭角型青光眼发病机制的认识主要以房角关闭为中心。其中解剖发现居于多数,相关概念和观点纷繁不一,但与发病机制的具体关系有待深入探讨。本文以房水外流阻滞为中心,依据“大后房”的概念及其与晶状体-虹膜隔相结合的观点,对房水外流通路的所有结构进行重新审视,以具体确定房水外流阻滞的易发环节。此外还梳理了常见术语的解剖属性及其与病理生理机制的联系,探讨了不同阻滞环节与不同亚型原发性闭角型青光眼的内在统一关系。期望为原发性闭角型青光眼发病机制的认识进一步提供病理生理学思路。(眼科, 2021, 30: 333-336)


关键词: 原发性闭角型青光眼, 发病机制, 病理生理学

Abstract: The existing understanding of the pathogenesis of primary angle-closure glaucoma(PACG) mainly centers on angle closure. Among them, the anatomical findings are the majority, and the related concepts and views are varied, but the specific relationship with the pathogenesis remains to be explored. This paper focuses on the outflow block of aqueous humor instead of angle closure. According to the concept of the “big posterior chamber” and the view of its combination with the lens-iris diaphragm, all the structures of the aqueous outflow pathway were reexamined and reintegrated to determine the predisposing links of outflow blocks. Furthermore, the anatomical properties of common terms and their connections with the pathophysiological mechanisms were largely sorted out, and the internal unified relationship between different blocking processes and different subtypes of PACG was also established. It is expected to provide a pathophysiological idea for understanding the pathogenesis of PACG. (Ophthalmol CHN, 2021, 30: 333-336)

Key words:  primary angle-closure glaucoma, pathogenesis, pathophysiology