Abstract: Objective To study concentration changes of serum magnesium, calcium, potassium, sodium and chloride ions in patients of primary retinitis pigmentosa (PRP). Design Retrospective case series. Participants 82 PRP patients and 99 normal control cases were enrolled from April 2013 to April 2014. Methods Patients with PRP were divided into four phases according to the severity of disease. The serum levels of magnesium, calcium, potassium, sodium and chloride were measured, and compared with that of control groups. Main Outcome Measures Serum levels of magnesium, calcium, potassium, sodium and chloride ions. Results Compared with normal group, the concentration of magnesium (0.845±0.067 mmol/L) was significantly lower than the normal group (0.874±0.076 mmol/L) (t=-2.688, P=0.008), but the levels of calcium (2.331±0.086 mmol/L vs 2.225±0.092 mmol/L) (t=5.672, P=0.000) and potassium (4.104±0.347mmol/L vs 3.897±0.310 mmol/L) (t=4.225, P=0.000) were significantly higher. Furthermore, it has been found that compared with normal group, in early phase of PRP, the magnesium (0.830±0.070 mmol/L)(P=0.001) was significantly lower, but the calcium (2.325±0.087 mmol/L) (P=0.000) and potassium (4.040±0.265 mmol/L)(P=0.017) were significantly higher. In late phase of PRP, the calcium (2.337±0.086 mmol/L) (P=0.000) and potassium (4.174±0.411 mmol/L) (P=0.000) were also significantly higher than that in normal group. Interestingly, the magnesium in late phase of PRP was significantly higher than that in early PRP (P=0.044). Conclusion In patients with PRP, the serum levels of magnesium, calcium and potassium are shown the changes, which probably related with occurrence of PRP.

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 retinitis pigmentosa, primary, serum concentration, magnesium, calcium, potassium, sodium, chlorine