Abstract:

Posterior capsular opacification (PCO) is the most common complication of cataract surgery. The main reason of PCO is that the lens epithelia cells (LEC) proliferation, migration, epithelial-to-mesenehymal transition, and extracellular matrix deposits, etc. Many signaling pathways such as TGF-β/Smads signaling pathway, PI3K/AKT signaling pathway, MAPK signaling pathway, Wnt signaling pathway, integrins signaling pathway, NF-κB signaling pathway, Rho/Rock signaling pathway play the important roles in maintaining the biological behavior of LEC related to PCO and become a hot topic nowadays. This paper mainly summarized the relationship of signaling pathways and PCO. It is important to explore the pathogenesis of PCO, which offers a new research idea for prevention of PCO.