Abstract:

The innervation of normal corneal nerve is critical in protective functions and maintaining the sensation of the cornea. Diabetic corneal neuropathy has the risk of corneal tissue injury, decreased sensitivity and visual impairment. The pathogenesis is not exactly clear, including glycometabolic disorder, peripheral neuropathy, oxidative stress and so on. Studys suggested that the lose of diabetic corneal nerve and the decrease of nerve fiber length and density was related with corneal sensation, diabetic retinopathy, dry eyes and other factors. The main treatment is to control blood glucose, nutrient nerve, promote the growth of nerve etc.