Abstract:

Corneal collagen cross linking has become the most effective treatment for corneal dilated diseases. The effect of tranditional epithelium-off corneal cross linking is well-known, but it take too much time on surgical time, and some patients showed side effects after surgery. In order to improve the surgical safety, some improved surgical techniques have been developed, include transepithelial corneal cross linking and  accelerated corneal cross linking, but there’s a lot of debate about the validity of these. The epithelium-off corneal cross linking is the most effective surgical method for now, the efficacy of epithelium-on and accelerated corneal cross linking in short term was well, but it still needs more long-term results to verify the effectiveness for treating keratoconus.