Abstract:

Proteomic is committed to study a proteome according to the time, space and cell types qualitatively and quantitatively, including protein expression and cellular localization, the protein-protein interaction, and protein modification after translation and protein turnover. The general research techniques used in proteomics include protein separation techniques and identification technology and bioinformatics analysis. The application of proteomics in fundus diseases research  mainly include  to screen typical proteins in vitreous and plasma, to explore the pathogenesis which different proteins may be involved, such as retinal degeneration and changes of retinal vascular permeability, and to optimize the treatment plan. Now the proteomic technology is used to explore the pathogenesis, diagnosis and treatment of age-related macular degeneration, idiopathic macular membrane, diabetic retinopathy, proliferative vitreoretinopathy, retinitis pigmentosa and so on.  (Int Rev Ophthalmol,  2017,  41:   52-55)