Abstract:

Monocyte chemoattrantact protein-1(MCP-1/CCL2) is an important proinflammatory chemokine in the many pathological and physiological processes, such as immune response, inflammatory reaction, which mediates monocytes and macrophages migrating and infiltrating in inflammatory tissues. Excessive secretion would lead to many systemic monocyte infiltrating diseases. Recent studies find that in many eye diseases, including ocular surface diseases, pouch contraction syndrome, glaucoma, uveitis,  retinal disease and so on, monocytes infiltrating is also a pivotal event. And there are some researches show that MCP-1 also participates in the occurrence, development and outcome of many monocytes infiltrating oculopathy，and inhibition of MCP-1 activity may be a new therapeutic target in relevant ophthalmology.(Int Rev Ophthalmol, 2018, 42:  307-311)