国际眼科纵览

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前弹力层移植的应用及进展

黎彪,吴园园,邵毅   

  1. 330006 南昌大学第一附属医院眼科
  • 收稿日期:2018-08-15 出版日期:2018-12-22 发布日期:2018-12-22
  • 通讯作者: 邵毅,Email: freebee99@163.com
  • 基金资助:

    国家自然科学基金(81660158,81400372);江西省自然科学基金重大项目(2016ACB21017); 江西省青年科学基金(20151BAB215016, 20161BAB215198);江西省重点研发项目(20151BBG70223)

The advancement and application of the Bowman layer transplantation

LI Biao, WU Yuan-yuan, SHAO Yi   

  1. Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, 330006 Nanchang, China
  • Received:2018-08-15 Online:2018-12-22 Published:2018-12-22
  • Contact: SHAO Yi, Email: freebee99@163.com
  • Supported by:

    National Natural Science Foundation of China (81660158,81400372); Natural Science Key Project of Jiangxi Province (20161ACB21017); Youth Science Foundation of Jiangxi Province (20151BAB215016, 20161BAB215198); Key Research Development Foundation of Jiangxi Province(20151BBG70223)

摘要:

前弹力层移植(Bowman layer transplanation, BLT)是一种微创的治疗方案,通过运用技术Ⅰ和技术Ⅱ提取出孤立的前弹力层(Bowman layer,BL),经过台盼蓝染色后在滑动的帮助下植入受体的角膜基质层口袋内,可改善角膜的稳定性,防止角膜扩张。圆锥角膜(keratoconus,KC)是一种表现为角膜中央锥形扩张,进而导致视力下降的先天性异常疾病。BLT首先用于阻止晚期KC的进展,不以提高视力而以保持功能性视力、减少术后严重并发症的发生为目标,有显著的疗效,能有效加强角膜结构稳定性,并且减少远期并发症。BLT也用于准分子激光屈光性角膜切削术(photorefractive keratectomy,PRK)术后角膜混浊的治疗中,能较好地恢复患眼视力。(国际眼科纵览, 2018,  42:    367-371)

Abstract:

Bowman layer transplanation (BLT) is a minimally invasive treatment protocol that uses Technique I and Technique II to extract an isolated Bowman layer (BL) that is slid into receptor substrate layer inside the pocket after trypan blue staining. BLT improves corneal stability and prevents corneal expansion. The keratoconus (KC) is a congenital anomalous disease characterized by a conical expansion of the central cornea, which in turn causes a decrease in vision. BLT was used to prevent the progression of advanced KC. The aim was not to improve visual acuity and maintain functional vision, but to reduce the occurrence of serious complications after surgery. The result showed significant curative effect. BLT could effectively strengthen the stability of the corneal structure and reduce long-term complications. In the treatment of corneal opacity after excimer laser photorefractive keratectomy (PRK), BLT can improve vision. (Int Rev Ophthalmol, 2018, 42: 367-371)