国际眼科纵览

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羊膜在眼表疾病治疗的研究进展

李楠钰 张文佳 胡竹林   

  1. 昆明医科大学第四附属医院、昆明医科大学;云南省眼科研究所;云南省眼科疾病预防防治重点实验室;云南省第二人民医院白内障与眼底疾病防治省创新团队;云南省姚克专家工作站650000
  • 收稿日期:2018-11-04 出版日期:2019-04-25 发布日期:2019-04-30
  • 通讯作者: 胡竹林,Email:Hu-zhulin@163.com
  • 基金资助:
    云南省科技计划项目重大科技专项(2018ZF009)、云南省眼科研究所、云南省眼科疾病研究重点实验室(2017DG008)、院士和领军人才培养(2017HC010)、院士专家工作站(2017IC064)、云南省卫生科技计划项目(2016NS182)

Advances in the treatment of ocular surface diseases by amniotic membrane

Li Nanyu, Zhang Wenjia, Hu Zhulin   

  1. The Fourth Affiliated Hospital of Kunming Medical University, Kunming Medical University, Yunnan Eye Institute, Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology, Provincial Innovation Team for Cataract and Ocular Fundus Disease, Expert Workstation of Yao Ke, Kunming 650000, China
  • Received:2018-11-04 Online:2019-04-25 Published:2019-04-30
  • Contact: Hu Zhulin, Email: hu-zhulin@163.com
  • Supported by:

    Science and Technology Project\|Major Project of Yunnan Province (2018ZF009);Key Laboratory of Yunnan Province for the Prevention and Treatment of ophthalmology(2017DG008); Provincial Innovation Team for Cataract and Ocular Fundus Disease, The Second People’s Hospital of Yunnan Province(2017HC010); Expert Workstation(2017IC064); Yunan Medical and Scientific Development Program (2016NS182)

摘要:

羊膜是眼病治疗中常用的辅助材料。随着组织工程的发展,以羊膜为基础制备的新型羊膜制品(如羊膜滴眼液、交联羊膜、药物羊膜和羊膜细胞培养载体等)不仅保留了羊膜的组织生物学特征(如低免疫原性、促进上皮形成、抗纤维化和抗炎性、抗新生血管形成、抗菌性等),还赋予了羊膜新的优良特性,使羊膜在眼表疾病(如急性或慢性化学性眼烧伤、持续性角膜上皮缺损、大泡性角膜病变、角巩膜溃疡等)治疗上更加方便、有效,展现了广阔的临床应用前景。(国际眼科纵览,2019, 43:94-99)

 

Abstract:

Amniotic membrane is a common auxiliary material used in the treatment of eye diseases. With the development of tissue engineering, new amniotic membrane preparations based on amniotic membrane (such as amniotic membrane eye drops, cross\|linked amnion, drug amnion and amniotic cell culture vectors) not only retain the histopathological characteristics of amnion (such as low immunogenicity, promotion of epithelial formation, anti\|fibrosis and anti\|inflammatory, anti\|angiogenesis, antibacterial, etc.), also confers new and excellent characteristics of amniotic membrane, making amniotic membrane more convenient and effective in the treatment of ocular surface diseases(such as acute or chronic chemical eye burns, persistent epithelial defect, foamy keratopathy, corneal and scleral ulcer, etc.), showing a broad prospects for clinical application.   (Int Rev Ophthalmol, 2019, 43:  94-99)