Abstract:

With the growth of age, all organs of the human body are experiencing the process of growth, development and decline, and the various tissues of the eyeball will change accordingly. Cornea is an important component of ocular surface barrier and refractive system. Its physiological state and pathological changes are closely related to the diagnosis and treatment of diseases. With the growth of age, corneal endothelial cells and nerve fibers decrease, corneal hypoesthesia, corneal density increases, proliferation activity of limbal cell population decreased, higher order aberrations increase, and biomechanical value decreases. It is necessary to study the age-related changes of cornea for understanding the occurrence and development of corneal diseases, designing effective and personalized treatment programs, observing the therapeutic effect, and formulating reasonable intervention measures. (Int Rev Ophthalmol, 2019, 43: 151-156)