国际眼科纵览 ›› 2012, Vol. 36 ›› Issue (1): 31-35.doi: 10-3760/ cma.j.issn.1673-5803.2012.01.007

• 综述 • 上一篇    下一篇

穿透性角膜移植排斥反应的免疫学机制

贾喆  张晓敏  赵少贞   

  1. 300384天津医科大学眼科中心
  • 收稿日期:2011-12-15 出版日期:2012-02-22 发布日期:2012-02-19
  • 通讯作者: 赵少贞,Email:zhaosz1997@sina.com

Immune mechanisms of penetrating keratoplasty rejection

JIA Zhe, ZHANG Xiao-min, ZHAO Shao-zhen   

  1. Tianjin Medical University Eye Center, Tianjin 300384, China
  • Received:2011-12-15 Online:2012-02-22 Published:2012-02-19
  • Contact: ZHAO Shaozhen, Email: zhaosz1997@sina.com

摘要: 尽管角膜具有众多特殊的免疫赦免机制,但CD4+T细胞为主介导的角膜移植排斥反应仍是术后最常见的并发症。本文从高危角膜移植对免疫赦免状态的影响、角膜免疫机制的应答以及排斥反应的预防及治疗几个方面阐述角膜移植排斥反应的最新进展。

Abstract: Although the cornea enjoys a remarkable degree of immune privilege, the CD4+T cellmediated immune rejection remains the most common cause of keratoplasty failure. This review  will focus on the latest progress of effect of highrisk corneal transplantation on immune privilege, the mechanism of corneal immune response, and prevention and treatment of corneal allografts rejection.