Abstract:

Long non-coding RNA (LncRNA) is a group of RNA molecules that are longer than 200 nucleotides and have a wide range of biological origins and highly conserved secondary and tertiary structures. LncRNA is rich in biological functions. They have only limited ability to encode proteins, and most of them regulate the expression of genes at the level of transcription, post-transcriptional level, and epigenetic modifications in the form of RNA. Recently,  it has been found that LncRNA plays an important role in retinopathy by regulating functions such as retinal vascular endothelium, pigment epithelial cells, and nerve cells, which provides certain strategies and directions for future research on prevention and treatment of retinopathy.