国际眼科纵览

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角膜神经纤维与干眼

程雨  晏晓明   

  1. 北京大学第一医院眼科 100034
  • 收稿日期:2019-02-26 出版日期:2019-08-22 发布日期:2019-08-26
  • 通讯作者: 晏晓明,Email:yanxiaoming7908@163.com E-mail:yanxiaoming7908@163.com
  • 基金资助:

    国家自然科学基金(81870629)

Corneal nerves and dry eye

Cheng Yu, Yan Xiaoming   

  1. Department of Ophthalmology, Peking University First Hospital, Beijing 100034, China
  • Received:2019-02-26 Online:2019-08-22 Published:2019-08-26
  • Contact: Yan Xiaoming, Email:yanxiaoming7908@163.com E-mail:yanxiaoming7908@163.com
  • Supported by:

    National Natural Science Fundation of China (81870629)

摘要:

干眼症状和体征不一致的现象让人们开始关注角膜神经在干眼中的作用。角膜神经纤维的结构可通过免疫组化或活体共聚焦显微镜详细观察,其在维持眼表稳态方面起关键作用。干眼可导致神经改变,同时,神经在稳态失衡时参与干眼的恶性循环,加重其症状体征。

Abstract:

Lack of correlation between signs and symptoms in dry eye has drawn attention to role of corneal nerves in dry eye. Structure of nerve fibers can be observed by histochemistry in vitro or confocal microscopy in vivo. Corneal nerves are key to ocular surface homeostasis. Dry eye leads to neural changes. The nerve, conversely, contributes to the vicious circle aggravating the disease.