Abstract:

Glaucoma is one of the leading course of irreversible blindness worldwide, of which the main characteristics include pathological high intraocular pressure and visual field defect. Filtration surgery plays an important role in the treatment of glaucoma. However, postoperative scarring of the filtration channel resultant from excessive proliferation of Tenon′s capsule fibroblasts (TCFs) reduces the long-term success rate of the surgery. In recent years, it has been suggested that presence of pigment granules in anterior segment of the eyeball may inhibit the proliferation of TCFs, which provides a novel thought and research direction for intro- and postoperative management of scarring in filtration surgery.