Abstract:

p38 MAPK signaling pathway mediates the transmission of information between cells through protein phosphorylation mechanism, which plays an important role in the occurrence and evolution of various diseases in the whole body. Ophthalmological diseases are also an important "target" for the role of p38 MAPK signaling pathway. p38 MAPK signaling pathway induces inflammatory factors in conjunctival epithelial cells, participates in the metabolism of lens epithelial cells and apoptosis of retinal ganglion cells through the mechanisms of inflammatory response, immune injury, oxidative stress, cell apoptosis and other mechanisms, and mediates the retinal inflammation and participates in retinal neovascularization. p38 MAPK signaling pathway is closely related to dry eye, cataract, glaucoma and retinal diseases and so on. This provides new ideas and methods for effective diagnosis and treatment of ophthalmic diseases.