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糖尿病视网膜病变斑马鱼模型的研究进展

李乐乐1 朱曼辉2 涂园园2 杨楷文3 刘东4 石运伟4 桑爱民1   

  1. 1南通大学附属医院眼科,江苏南通 226000;2苏州大学附属理想眼科医院,江苏苏州 215008;3南通大学杏林学院,江苏南通 226000;4南通大学 江苏省神经再生重点实验室,江苏南通 226000
  • 收稿日期:2019-08-03 出版日期:2020-02-22 发布日期:2020-02-27
  • 通讯作者: 桑爱民,Email: sangam@ntu.edu.cn E-mail:sangam@ntu.edu.cn
  • 基金资助:
    江苏省研究生科研与实践创新计划(CJCX180829)

Research progress on zebrafish model of diabetic retinopathy

Li Lele1, Zhu Manhui2, Tu Yuanyuan2, Yang Kaiwen3, Liu Dong4, Shi Yunwei4, Sang Aimin1   

  1. 1 Department of Ophthalmology, the Affiliated Hospital of Nantong University, Nantong 226000, China; 2 Lixiang Eye Hospital of Soochow University, Suzhou 215008, China; 3 Nantong University Xinglin College, Nantong 226000, China; 4 Jiangsu Key Laboratory of Neuroregeneration,  Nantong University, Nantong 226000, China
  • Received:2019-08-03 Online:2020-02-22 Published:2020-02-27
  • Contact: Sang Aimin, Email: sangam@ntu.edu.cn E-mail:sangam@ntu.edu.cn
  • Supported by:
    Jiangsu Province Graduate Research and Practice Innovation Plan(CJCX180829)

摘要: 糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病性微血管病变中最重要的表现,是一种具有特异性改变的眼底病变,糖尿病的严重并发症之一。DR具体发病机制仍不明确,目前尚无有效的治疗措施。斑马鱼作为一种模型动物,能够通过一定的处理很好地模拟糖尿病及DR的发病过程,如DR早期眼底微血管瘤样改变。同时,斑马鱼也可以为新研发药物的治疗效果提供可靠的参考。

Abstract: Diabetic retinopathy (DR) is the most important manifestation of diabetic microangiopathy. It is a kind of fundus lesion with specific changes, one of the serious complications of diabetes. The specific pathogenesis of DR remains unclear, and there are no effective treatments. As a model animal, zebrafish can well simulate the pathogenesis of diabetes and DR through certain treatments. Some scholars have found that zebrafish can simulate early fundus aneurismlike changes in DR. At the same time, zebrafish can also provide a reliable reference for the therapeutic effects of newly developed drugs.