Abstract:

During the perioperative period of glaucoma filtration surgery, prevention and inhibition of scar formation in filtration canal is the key for long-term success.  Anti-scarring treatments for filtration canal after glaucoma surgery include non-specific anti-inflammatory or anti-metabolite drugs(such as 5-fluorouracil, mitomycin C, glucocorticoids, etc), specific drugs that target certain receptors or interfere signaling pathway(such as anti-vascular endothelial growth factor, drugs acting on transforming factor pathways etc),  as well as drug delivery system(such as degradable collagen matrix, γ-cyclodextrin and chitosan). (Int Rev Ophthalmol, 2018, 42:  289-296)