急性闭角型青光眼视神经损害及机制的研究进展
解梦 樊宁 田祥 彭玉豪 刘旭阳
- 563003贵州，遵义医学院附属医院眼科（解梦、田祥）；518040 深圳，暨南大学附属深圳市眼科医院（樊宁、刘旭阳）；Department of Pharmaceutical Sciences and North Texas Eye Research Institute, University of North Texas Health Sciences Center, Fort Worth, Texas 76107, United States（彭玉豪）
Optic nerve damage and its mechanism in acute angle-closure glaucoma
XIE Meng1, FAN Ning2, TIAN Xiang1, Iok-Hou Pang3, LIU Xu-yang2
- 1. Department of Ophthalmology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China; 2. Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, China; 3. Department of Pharmaceutical Sciences and North Texas Eye Research Institute, University of North Texas Health Sciences Center, Fort Worth, Texas 76107, United States
摘要：
急性闭角型青光眼是前房角突然关闭而引起眼压急剧升高的一种青光眼类型，在亚洲人中的发病率较高。其引起的视神经损害主要表现为杯盘比扩大、视网膜神经纤维层缺失和视野缺损等。迄今有关其视神经损害机制的研究主要集中在机械压力因素、血管及血流动力学因素、分子因素等方面。一氧化氮、视网膜内谷氨酸水平与Ca2+超载、内皮素-1、大胶质细胞活化、自身免疫功能失调可能会导致急性闭角型青光眼视神经损害。