国际眼科纵览

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T细胞及其细胞因子在过敏性结膜炎作用机制的研究

宁婵慧  李冰  郑晓汾   

  1. 030001 山西医科大学(宁婵慧系在读硕士研究生); 030002 山西省眼科医院(李冰、郑晓汾)
  • 收稿日期:2014-06-17 出版日期:2015-10-22 发布日期:2015-10-27
  • 通讯作者: 郑晓汾 E-mail:zxffd@163.com

T-lymphocyte and its cytokines in allergic conjunctivitis

NING Chan-hui1, LI Bing2, ZHENG Xiao-fen2.   

  1. 1.Shanxi Medical University, 030001 Taiyuan, China; 2.Shanxi  Eye Hospital, 030002 Taiyuan, China
  • Received:2014-06-17 Online:2015-10-22 Published:2015-10-27
  • Contact: ZHENG Xiao-fen E-mail:zxffd@163.com

摘要:

过敏性结膜炎是机体在遇到外界抗原时,免疫系统表现出的一种眼部异常超敏反应,其症状涉及整个眼表,包括眼睑、结膜、角膜、泪膜,患者表现为眼睑水肿、痒、结膜充血、流泪、畏光等,严重影响患者的健康和生活。过敏性结膜炎的发病机制尚不完全清楚,涉及IgE介导的Ⅰ型超敏反应,也有T淋巴细胞介导的细胞免疫反应。本文讨论T细胞及其细胞因子在过敏性结膜炎发病机制中作用的研究现状。(国际眼科纵览,2015,39:357.360)

Abstract:

Abstract】Allergic conjunctivitis is an abnormal hypersensitivity response of the immune system to commonly encountered antigens. It is considered a syndrome that comprises the entire ocular surface,including lids,conjunctiva,cornea and tear film.The symptoms include eyelid edema,itching,conjunctival redness,tearing and light sensitivity.These symptoms and signs affect patients, healthy and life seriously.The pathophysiology of allergic conjunctivitis is not completely clear. As far as we know,allergic eye disease might be caused by an immunoglobulin E(IgE)-mediated type Ⅰhypersensitivity reaction,or a T-lymphocyte-mediated cellular immune response.This article mainly discuss the research status of T lymphocytes and its cytokines of allergic conjunctivitis and make a summary of its pathogenic mechanism.(Int Rev Ophthalmol,2015,39:357.360)