Abstract:

Age-related macular degeneration is the main cause of blindness of elderly patients and its prevalence has been increasing worldwide. Despite close attention was paid on AMD, its pathogenesis is still not fully understood and the research has been regarded as an essential project in vision science. Autophagy refers to the process which targeted proteins and organelles were packaged and transported for degradation in lysosome，which is a major catabolic pathway involved in maintaining intracellular homeostasis. Mutiple researches suggested that autophagy also has a close relationship with AMD-related pathogenesis such as oxidative stress, inflammation and retinal pigment epithelium disorders,which may present some ideas of autophagic treatment for AMD.