Abstract:

The occurrence and development of angiogenesis involves the complex biological processes of multiple growth factors and their receptors. Many growth factor receptors are tyrosine kinase receptors. Protein tyrosine kinases play an important role in the occurrence and development of new blood vessels. The biological activity of growth factors needs to bind to its target cell receptors and activate receptor tyrosine kinase. The structure of  protein tyrosine kinase is changed to produce the enzyme catalytic effect, which can cause the biological effect, thus promoting the formation of new blood vessels. Searching for selective tyrosinase inhibitors to block or regulate the disease caused by abnormal activation of these pathways is a research strategy of anti angiogenesis drugs. (Int Rev Ophthalmol,  2017,  41:    83-87)