国际眼科纵览

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干细胞移植治疗视网膜和视神经变性疾病的现状和进展

李晓虹  吴仁毅   

  1. 361001 厦门大学附属厦门眼科中心厦门大学眼科研究所(李晓虹系在读硕士研究生)
  • 收稿日期:2017-04-05 出版日期:2017-06-29 发布日期:2017-06-29
  • 通讯作者: 吴仁毅,Email: wubasel@hotmail.com
  • 基金资助:

    国家自然科学基金(81170841、81570844);厦门市科技项目(3502Z20134040、3502Z20149026)

Current approaches and future prospects of stem cell transplantation for degenerative diseases of retina and optic nerve

LI Xiao-hong, WU Ren-yi.   

  1. Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, Xiamen 361001,  China
  • Received:2017-04-05 Online:2017-06-29 Published:2017-06-29
  • Contact: WU Ren-yi, Email: wubasel@hotmail.com
  • Supported by:

    National Natural Science Foundation of China (81170841, 81570844); Xiamen Scientific and Technologic Fund Program (3502Z20134040, 3502Z20149026)

摘要:

不可逆性的视网膜和视神经退行性变会导致视功能严重损伤甚至致盲。近年来,干细胞移植治疗视网膜和视神经损伤的研究进展为组织的修复和再生带来了希望。干细胞既可以用于细胞替代治疗,也可以通过分泌细胞因子发挥神经营养保护作用。胚胎干细胞、间充质干细胞、诱导多能干细胞和Müller细胞等各种来源的干细胞都极具发展前景,为眼科此类难治性疾病提供了丰富的资源。(国际眼科纵览, 2017, 41: 153-158)

Abstract:

Irreversible chronic retinal degenerative diseasesare the main pathology of visual loss, and current clinical management often fails to prevent disease progression.In recent years there has been substantial progress in developing stem cell treatments for these diseases. Stem cell therapy has the potential to both replace lost, and protect damaged, cells by secreting neurotrophic factors. A variety of sources, including embryonic stem cell (ESC), mesenchymal stem cell (MSC), induced pluripotent stem cells (iPSC) and Müller cells show promise as therapeutic approaches for future cell regenerative medicine.(Int Rev Ophthalmol,  2017, 41: 153-158)