Abstract:

Limbal stem cells play an important role in corneal epithelial regeneration and wound healing. Iimbal stem cell deficiency can lead to a variety of serious ocular surface disorders. Because of autologous transplantation with healthy eye damage, allograft rejection and donor problems,  the stem cell research and tissue engineering development have great challenge and chance.  In vitro cultured limbal stem cells can construct tissue-engineered corneal epithelium and then use for transplantation in the treatment of disease of limbal stem cell lack. This paper summarized the new progress on seed cells and Scaffold material selection two aspects and  explored the existing problems and further development.(Int Rev Ophthalmol,  2017,  41:   346-351)