Abstract: The etiology of myopia involves a complex regulatory process of the retina-choroid-sclera axis, wherein the Wnt/β-catenin pathway plays a pivotal role as a significant signaling pathway in myopia development. Studies indicate that activation of the Wnt/β-catenin pathway correlates positively with the severity of myopia, and inhibiting this pathway may potentially slow the progression of myopia. Moreover, individuals with myopia exhibit significantly reduced levels of DKK-1 (Dickkopf-1) in their blood, and supplementation of DKK-1 may mitigate axial elongation of the eye and progression of myopia. These findings pave the way for novel research directions in therapeutic strategies based on the Wnt/β-catenin pathway.(Int Rev Ophthalmol, 2024, 48:  433-437)

Key words: Wnt/β-catenin signaling pathways, myopia