Abstract: Autophagy is the major patho/physiological process for lysosomal degradation and recycling of cytosolic organelles and protein, playing a key role in the cellular homeostasis. Increasing evidences had shown that autophagy is closely associated with the pathogenesis and progression of a number of ocular disorders including glaucoma. Autophagy is activated in retinal ganglion cells and trabecular meshwork cells and has an important role after intraocular pressure elevation. Mutations in the autophagy receptor OPTN/optineurin are reported to associate with the pathogenesis of glaucoma. Strategies aimed at regulating autophagy may lead to therapeutic interventions for glaucoma.   (Int Rev Ophthalmol, 2014, 38:   366-369)