Abstract: Corneal neovascularization (CNV) occurs in many ocular diseases, which is one of the main factors affecting corneal transparency. MicroRNA is closely related to pathological CNV, and can affect the generation of CNV by regulating the expression of various cytokines and signal pathways. It mainly includes miRNA that inhibit CNV (such as miR-184, miR-204) and miRNA that promote CNV (such as miR-126, miR-132, miR-21, and miR-27a/b).  Regulation of these miRNAs is expected to be therapentic method for CNV. The antisense miRNA oligonucleotide antigomir can be used to inhibit the endogenous miRNA effect in promoting curred angiogenesis.(Int Rev Ophthalmol, 2020, 44：192-196)