Abstract: Under physiological conditions, radicals on cellular activities play an important role. When the body is subjected to noxious stimuli lead to oxidative stress, the increased production or decreased removal of radicals result in oxidative damage to cells and tissues. Diabetic cataract is one of the complications of diabetes, and an important class of blinding eye disease. Currently its pathological mechanisms were considered including polyol pathway activation, oxidative stress and non\|enzymatic glycation of lens proteins. Oxidative stress action as a central part is attractive, which is closely related to the generation of diabetic cataract. The development of nzymatic and non\|enzymatic antioxidant defense systems provides a strategy for anti\|cataract, and provides a new idea for mitigation and prevention of diabetic cataract studies.   (Int Rev Ophthalmol, 2015, 39： 94-98)