Abstract: Severe eyelid full-thickness defect seriously endangers the health and appearance of the eye surface, and the reconstruction requires the replacement of the external musculocutaneous layer as well as the internal mucosal layer. The defect of the anterior eyelid can be covered with various local flaps (such as kite flap, gliding flap, rotating flap, etc.) and free flaps. The defect of the posterior eyelid needs to be reconstructed by selecting appropriate meibomian, meibomian conjunctival composite tissue or conjunctival substitute materials including autogenous tissue, allogeneic tissue and synthetic materials.  (Int Rev Ophthalmol, 2020, 44：207-213)