Abstract: IgG4-related ocular disease ( IgG4-ROD) is a kind of autoimmune disease with a large number of lymphocyte and plasma cell infiltration, obliterative phlebitis and sylvan or whirlpool fibrosis. It can involve many eye tissues or organs, such as lacrimal gland, extraocular muscle, orbital fat and trigeminal nerve. Its main clinical manifestations are chronic painless swelling and / or exophthalmos on both or one side of the orbit, which may be accompanied by peripheral Lymphadenopathy, usually not obvious visual impairment, but serious can make function loss of the involved tissues and organs and affect the daily life of patients. The pathogenesis of IgG4-ROD is not clear. According to the existing literature, it may be related to the production of autoantibodies, microbial infection and genetic factors. For the treatment of IgG4-ROD, at present, glucocorticoids, immunosuppressants, biological agents and surgical treatment are the main clinical methods. Although these treatment methods can achieve certain efficacy, there are certain limitations such as high recurrence rate, serious side effects and postoperative complications.