International Review of Ophthalmology

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Optic nerve damage and its mechanism in acute angle-closure glaucoma

XIE Meng1,  FAN Ning2,  TIAN Xiang1,  Iok-Hou Pang3,  LIU Xu-yang2   

  1. 1. Department of Ophthalmology,  Affiliated Hospital of Zunyi Medical College,  Zunyi 563003, China; 2. Shenzhen Eye Hospital,  Jinan University,  Shenzhen 518040, China; 3. Department of Pharmaceutical Sciences and North Texas Eye Research Institute,  University of North Texas Health Sciences Center,  Fort Worth,  Texas 76107,  United States
  • Received:2015-03-10 Online:2015-08-22 Published:2015-09-07
  • Contact: LIU Xu-yang, Email: xliu1213@126.com E-mail:xliu1213@126.com

Abstract:

Acute angle-closure glaucoma (AACG) results from anterior chamber angle closed suddenly which causes an elevated intraocular pressure, and its incidence is higher in Asians. The manifestations of the optic nerve damages are the enlargment of cup-disc ratio, retinal nerve fiber layer defect and visual field defect. Yet the mechanisms underlying the optic neuropathy remain unknown.It has been focused on the mechanical stress,hemodynamic factors,and an improved knowledge of molecular mechanisms up to now. Researchers find that NO,  glutamate levels  and calcium overload in retina,  endothelin - 1,  glial cell activation,  and immune dysfunction may result in the damages of optic nerve in acute angle-closure glaucoma.