Abstract:

Mechanical factor plays an important role in regulating cellular function and structure. The abnormal mechanical response of cell may lead to a series of pathological changes. Due to the influence of intraocular pressure and other factors, the ocular cells are in a dynamic mechanical environment. The effects of different types of mechanical stimuli on ocular cells attribute to both the physiology and pathology of various ocular tissues. This paper summarized the progress of mechanobiology research of corneal cells, scleral cells, trabecular meshwork cells, cells in the lamina cribiosa region and retinal cells, and discussed the possible pathogenesis of related ocular diseases from biomechanical aspect, in order to provide new ideas for disease prevention, diagnosis and treatment. (Int Rev Ophthalmol, 2017, 41: 305-311)