Abstract:

Periostin, a secretory extracellular matrix protein that is expressed in a variety of tissues and organs, regulates cell movement by binding with integrin αvβ1, αvβ3 and αvβ5. It plays an important role in tissue development and remodeling. Periostin can induce angiogenesis and the deposition of extracelluar matrixes such as collagens and fibronectin, participating in a variety of physiological and pathological processes of fibrosis. Proliferative vitreoretinopathy, proliferative diabetic retinopathy and age-related macular degeneration are characterized by the formation of fibrous membranes in the vitreous or above and beneath the retina. There is an association between periostin and the formation of fibrous membrane and angiogenesis in vitreoretinal diseases.(Int Rev Ophthalmol, 2018, 42:  149-153)