Abstract:

Corneal stromal cells(CSCs), normally in a static state, are prone to change in phenotype and physiological functions when damaged. They can transform into fibroblasts or myofibroblasts. Different injury factors affect the response of corneal cells and determine whether corneal tissue is repaired completely or to form scar tissue. CSCs can synthesize and secrete a variety of extracellular matrix. Activated CSCs are beneficial to repair corneal injury. Corneal myofibroblast may cause turbidity of corneal surface. Injury, infection of bacteria or virus and other factors lead to scarring. Platelet rich plasma, TGF-β and other physicochemical factors play an important role in phenotypic transformation of CSCs, clinical treatment and prevention of corneal scar tissue.(Int Rev Ophthalmol, 2018, 42:  194-198)