Abstract: Infectious keratitis is a risk of corneal related blindness, and anti-infection is the main treatment approach, while the glucocorticoid therapy remains controversial. The appropriate utilization of the glucocorticoid in different infectious keratitis could be helpful for the anti-inflammatory effect and release the complications. It was suggested that the glucocorticoid could be used in the bacterial keratitis after 48 hours antibiotic treatment, which can reduce the formation of corneal scarring. The glucocorticoid used in the viral keratitis is still limited in the stromal and endothelial infection, which could obviously alleviate the inflammation. Glucocorticoids are easily worsen the exacerbation of fungal keratitis, so it could be only used after the fungal infection was controlled. Glucocorticoid utilized in acanthamoeba keratitis has gotten some progress in the basic research, but still no consensus on the timing of use. (Int Rev Ophthalmol, 2022, 46: 45-50)

Key words: infectious keratopathy, glucocorticoid