Abstract: Eye drop solutions are widely used by the ophthalmologist to treat the anterior segment eye diseases. However, eye drop solutions have many limitations including low bioavailability, high dose requirements, and poor patient compliance. Contact lenses are used to deliver the ocular drugs with high ocular bioavailability due to their immediate location to ocular surface. Based on the contact lenses, loading conventional drugs are used to explore the feasibility and potential to treat anterior eye disorders. Drug incorporated to the lens body is achieved with techniques, like simple soaking, inclusion of drug-loaded colloidal nanoparticles, or molecular imprinting. No matter what technique used, the key properties of the contact lens maintain unchanged, such as transparency and oxygen permeability. The drug delivery system based on contact lenses can effectively prevent and control ocular surface infection,promote corneal injury healing,treat allergic conjunctivitis,improve dry eye symptoms,and reduce intraocular pressure. It provides a new way for diagnosis and treatment of anterior segment disease. (Int Rev Ophthalmol, 2022, 46: 236-241)

Key words: contact lens, anterior segment disease, drug delivery system