Ophthalmology in China

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Long-term outcomes of ultrasound biomicroscopy in eyes with primary angle closure suspect after laser peripheral iridotomy: a five-year progression study 

LV Ai-guo1, 2, MU Da-peng3, GUO Li-xia2, LIANG Yuan-bo4, LI Si-zhen5, CUI Hong-yu2, ZHANG Zhi-hong2, FAN Su-jie2   

  1. 1. Chengde Medical College of Hebei Province, Chengde 067000, China; 2. Handan Eye Hospital, Hebei 056001, China; 3. Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; 4. The Affiliated Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, China; 5. Nanjing Aier Eye Hospital, Nanjing 210006, China
  • Received:2015-11-06 Online:2016-01-25 Published:2016-01-28
  • Contact: FAN Su-jie,Email:fansujie3@163.com


 Objective To quantitatively evaluate the long-term changes in anterior segment morphology with ultrasound biomicroscopy (UBM) after laser peripheral iridotomy (LPI) in eyes with primary angle closure suspect (PACS). Design Prospective case series study. Participants 42 PACS consecutive patients in Handan Eye Hospital, Hebei were enrolled. Method LPI was performed in one eye selected randomly for every PACS. Routine ophthalmic tests and UBM examination were performed at presentation and 5 years after LPI. Main Outcome Measures The parameters of anterior chamber angle ahead 500 μm and 750 μm of scleral spur, such as angle opening distance (AOD), trabecular-iris angle (TIA), angle recess area (ARA) trabecular-ciliary process distance (TCPD) and iris thickness (IT) on UBM images. Results The mean follow-up period was (5.2±0.5) years in 42 patients. AOD500, AOD750, TIA500, TIA750, ARA500, and ARA750 were significantly widen at 5 years after LPI than that at presentation in eyes with PACS (all P<0.001). IT500, IT750 were significantly decreased 11% and 6% respectively at 5 years after LPI than that at presentation in eyes with PACS (all P<0.001), and the parameters at 750 μm anterior to the sclera spur were more significantly wide than its 500 μm counterpart. Conclusion LPI can significantly widen the peripheral anterior angle in eyes with PACS and this effectiveness to be sustained at least 5 years after LPI.  (Ophthalmol CHN, 2016, 25: 23-29)

Key words: primary angle closure suspect, laser peripheral iridotomy, ultrasound biomicroscopy