Abstract:  It’s difficult to interpret the images of indocyanine green angiography (ICGA). For most ophthalmologists, they have been familiar with fundus fluorescein angiography (FFA) prior to ICGA. It’s reasonable for them to interpret ICGA with the same philosophy with FFA, whereas which would result to misunderstanding and misjudging. With the development of high-resolution optical coherence tomographic angiography, attention is less and less paid on ICGA. And the conception is up and up that FFA and ICGA can be replaced by OCTA and even be abandoned. This article analyzes the reasons which cause such misunderstandings and explores in depth the clinical values of ICGA, focusing on the irreplaceability of ICGA in demonstrating the choroidal circulation, evaluating the function of retinal pigment epithelium, illuminating the Bruch’s lesions rather than other multi-model imaging methods. It’s critical to widely apply ICGA and grasp its’ interpretations.

Key words: indocyanine green angiography, retinal pigment epithelium, multi-model imaging