Abstract:

Objective To evaluate the effect of bromfenac sodium eye drop on reducing eye pain before panretinal photocoagulation (PRP), and its timing of administration. Design Prospective case series. Participants From November 2016 to January 2018, 69 patients with severe non-proliferative diabetic retinopathy (sNPDR) or proliferative diabetic retinopathy (PDR) and required PRP were included. Methods The patients were randomized to trial group 1, trial group 2 or control group. All patients received PRP treatment 2 times. In trial group 1 and trial group 2, patients were treated with bromofenac sodium eye drop at the 3-day or 1-day before PRP treatment, respectively. In control group, patients were treated with sodium hyaluronate eye drop at the 3-day before PRP treatment. After the first and second PRP treatment, visual analogue scale questionnaire was used to evaluate the pain level during PRP treatment, including visual analogue scale/score (VAS) and present pain intensity (PPI). At the same time, the adverse reactions of topical bromfenac sodium eye drop and sodium hyaluronate eye drop were recorded. Main Outcome Measures VAS and PPI after the first and second PRP treatment. Result VAS after the first PRP treatment was 3.574±1.668 in trial group 1, 4.110±1.664 in trial group 2, and 4.255±1.900 in control group. There was no statistical difference among 3 groups, but there was a trend of gradual increase. After the second PRP treatment, VAS in trial group 1 and trial group 2 were significantly different from those of control group. The VAS score of control group was statistically different between the two PRP treatments (P=0.006). In the other two groups, there was no statistically significant difference in VAS scores between the first and second PRP treatments. In addition, there was no significant difference in PPI scores between the first and second PRP treatments among 3 groups. Conclusion Bromfenac sodium eye drop application pre-PRP treatment can alleviate laser pain of sNPDR/PDR patients. Application 3 days before PRP treatment shows better effect than 1 day. (Ophthalmol CHN, 2019, 28: 280-284)

Key words: panretinal photocoagulation, bromfenac sodium eye drop