Abstract:  Objective To analyze the clinical features of Vogt-Koyanagi-Harada(VKH) syndrome in children. Design Retrospective case series. Participants 9 children (18 eyes) with VKH syndrome. Methods The medical records data were analyzed retrospectively. Main Outcome Measures symptoms, signs, and treatment effects. Results The mean age of onset was (10.8±2.4) years in 9 patients. The average follow-up was (8.1±6.1) months. 7 cases (77.8%) had prodromal symptoms before the onset of the disease, including 3 cases (42.8%) of cold-like symptoms, 2 cases (28.6%) of tinnitus headache, and 2 cases (28.6%) of headache. 2 cases were combined with joint symptoms and recurrent oral ulcers. 3 cases were infected with mycobacterium tuberculosis. One case occurred after measles vaccination. Two cases were treated with adalimumab (ADA), one of which was used in the early stage, and the other was used after 5 months of treatment because of the abnormal choroidal thickness. At the end of follow-up, the uncorrected visual acuity of 14 eyes (77.8%) was ≥0.6 and 4 eyes (22.22%) <0.3, mainly in children whose symptoms appeared more than 30 days after the first systemic corticosteroid treatment. Of the 9 patients, 3 had no complications, and one of them was observed in the early combination treatment with ADA. Conclusion Infection and vaccination may be the inducing factors of VKH syndrome in children. Attention should be paid to the screening of tuberculosis infection before treatment, and the combination of ADA can improve the treatment response. (Ophthalmol CHN, 2024, 33: 350-355)

Key words:  Vogt-Koyanagi-Harada syndrome, children