Abstract: Objective To analyze histopathological characteristics and types of bilateral lacrimal gland prolapsed disorders. Design Retrospective case series. Participants 58 patients with bilateral lacrimal gland prolapsed disorders were surgically treated and were diagnosed pathologically in Beijing Tongren Hospital from 2010 to 2015. Methods The patients’ case history, symptoms, orbital imaging data of CT, MRI and the histopathological data were reviewed. Main Outcome Measures Pathological diagnosis. Results Of the 58 patients 36 (62.06%) were diagnosed as bilateral lacrimal gland prolapse, 22 cases (37.93%) had other lacrimal gland disorders. Of the 36 patients with lacrimal gland prolapsed, 25 cases (69.44%) had the pathological changes of focal lymphocytic infiltration, 11 cases (30.56%) had no evident pathological changes. Among all the 58 patients with bilateral lacrimal disorders, 25 cases (43.10%) had focal lymphocytic infiltration, 18 cases (31.03%) had Mikulicz disease, 3 cases (5.17%) had the subset of dacryoadenitis attributed to idiopathic orbital inflammation, 1 case (1.72%) had extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-EMZL), and 11 cases (18.96%) had no significant changes in lacrimal tissue. Conclusion The bilateral lacrimal gland prolapse disorders should differentiated from the subset of dacryoadenitis attributed to idiopathic orbital inflammation, early stage Mikulicz disease and MALT-EMZL at the lacrimal gland area. Of the patients with bilateral lacrimal gland prolapse, two-thirds of the patients’ lacrimal glands had focal lymphocytic infiltration changes to different extents. (Ophthalmol CHN, 2016, 25: 251-255)

Key words: lacrimal gland prolapse/ pathology, idiopathic orbital inflammation, Mikulicz disease, lymphoma